USE OF ANTI-TUMOR PEPTIDES IN HEAD AND NECK CANCER.

Autor: GONZAGA, Wigney Junior Carvalho, QUEIROZ, Pedro Paulo Borba, CAMPOS, Enzo Lustosa, PAIVA, Pamela Luquetti, LEAL, Eduarda Fernandes, LORENZON, Esteban Nicolas, MIRANDA, Carla Silva Siqueira
Zdroj: Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology; Jun2024, Vol. 137 Issue 6, pe310-e310, 1p
Abstrakt: Introduction: in the face of scientific knowledge, membranolytic, antineoplastic peptides emerge, which can interrupt the cell cycle and induce the immune response. From this, the pharmacological potential of these substances has been increasingly investigated. to detail the use of antitumor peptides in patients with head and neck cancer. literature review in the "Pubmed" and "BVS" databases, with 5 selected articles, written between 2005 and 2022. The descriptors were: peptides, antitumors, oral cancer, and cells. studies prove the extension of the life of species, as well as a reduction in the severity of adverse effects induced by traditional treatment, via the use of the AMP-18 peptide. They provoked apoptosis in cells, mitochondrial oxidative stress, energy damage and activation of apoptotic pathways, capable of stopping the cell cycle and breaking the plasmatic membrane, by the use of NRC-03 and Lfn-p. Also, selective cytotoxic effects on human oral cancer cells are suggested by the use of BmKn-2. this possible treatment with peptides is capable of inhibiting external cells and cell invasion, as well as reducing the expression of transcription factors. Thus, the selective antineoplastic effect may be a candidate treatment for oral cancer. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index