| Abstrakt: |
A 40-year-old woman presented with a painless ulcerated nodule on her upper lip that had been present for 3 months. The patient initially described the lesion as a "darkened spot," which had previously been treated by another clinician as herpes but showed no improvement. Upon examination, a dentist considered the possibility of an infectious process and conducted an incisional biopsy. Under microscopic examination, the biopsy revealed a proliferation of large lymphoid cells with significant pleomorphism, mitotic figures, eosinophils, and areas of necrosis. These neoplastic cells were observed to infiltrate muscle bundles, and some displayed kidney-shaped nuclei. Immunohistochemical analysis demonstrated positivity for LCA, CD30, CD4, CD8, CD68, Granzyme B, and a Ki-67 index of approximately 50%. Conversely, CD20, CD79a, MUM1, ALK, and CD56 were all found to be negative. Furthermore, in situ hybridization for EBV yielded a negative result. Remarkably, three weeks after the surgical procedure, the patient returned with complete regression of the lesion. Based on the clinical, histopathological, and immunohistochemical findings, the diagnosis of primary mucosal CD30-positive T-cell lymphoproliferative disorder was established. [ABSTRACT FROM AUTHOR] |
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