| Autor: |
VIEIRA, Gustavo de Souza, CHONE, Carlos Takahiro, de ARRUDA, Taciane Adami, MACEDO, Ligia Traldi, EGAL, Erika Said Abu, ALTEMANI, Albina Messias, MARIANO, Fernanda Viviane |
| Zdroj: |
Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology; Jun2024, Vol. 137 Issue 6, pe251-e252, 2p |
| Abstrakt: |
A 47-year-old male patient initially presented with a 5-month history of headaches and diplopia. He had no reported comorbidities. An MRI revealed an expansive image affecting the ethmoid sinus and nasal cavity bilaterally (56x40x37mm), extending intracranially and into the orbits. Subsequent incisional biopsy analysis confirmed a diagnosis of sinonasal undifferentiated carcinoma (T4aN0M0). The patient underwent induction chemotherapy with the TPF protocol, in addition to CDDP cycles, combined with high-dose radiotherapy, resulting in complete remission. After 45 months of follow-up, the patient experienced a painful midfacial swelling. A CT scan revealed a destructive image extending from the maxillary sinus to the intracranial region, accompanied by multiple regional lymphadenopathies. Microscopic examination indicated a poorly differentiated tumor with large round cells. An immunohistochemistry panel showed positivity for epithelial markers and a diffuse expression of neuroendocrine markers (CD56 and synaptophysin), a feature not previously observed in the initial lesion. This led to a diagnosis of large cell neuroendocrine carcinoma, and the patient underwent surgical-oncologic treatment, followed by subsequent follow-up. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full Text from ScienceDirect