LANGERHANS CELL HISTIOCYTOSIS IN A PEDIATRIC PATIENT.

Autor: EWBANK, Julia Morato, PESSÔA, Thiago Moreira, VIEIRA, Marina Urquiza Lopes, RAMOS, Ruth Tramontani, DICK, Thaylla Núñez Amin, dos SANTOS, Teresa Cristina Ribeiro Bartholomeu, PIRES, Fabio Ramoa
Zdroj: Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology; Jun2024, Vol. 137 Issue 6, pe240-e240, 1p
Abstrakt: A one-year-old girl was brought to the stomatology clinic with a complaint of a lesion in the maxilla. Upon head and neck examination, red scaly lesions were observed on the head and auricular region, indicative of seborrheic dermatitis. Intraoral examination revealed an exophytic tumoral lesion with a granular surface, measuring approximately 3 cm, located in the upper right alveolar ridge, extending from tooth 53 to 55. This lesion had been present for one year. Radiographs displayed an ill-defined radiolucent image in the affected area. Based on the clinical findings, a provisional diagnosis of Langerhans cell histiocytosis was made, and an incisional biopsy was performed. Histological examination of the hematoxylin and eosin (HE) stained slides revealed a proliferation of neoplastic histiocytes, consistent with Langerhans cells, along with numerous eosinophils. Immunohistochemical analysis showed that the neoplastic cells were positive for S100 and CD1a expression, confirming the diagnosis of Langerhans cell histiocytosis. The patient was subsequently referred to Pediatric Hematology/Oncology for further evaluation and management. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index