| Abstrakt: |
Low-grade fibromyxoid sarcoma (LGFS) has been documented in the oral and maxillofacial region. Occasionally, as previously noted, odontogenic (fibro)myxoma can present histological features resembling LGFS. A 29-year-old female was referred due to discomfort while chewing, which had started one month earlier. Intraoral examination revealed a painless tumoral mass in the posterior maxillary region, resulting in tooth displacement. Panoramic radiography displayed an irregular radiolucent lesion, and CT scans indicated a hypodense area, causing cortical bone expansion with involvement of the maxillary sinus. Following an incisional biopsy, microscopic examination revealed extensive areas containing spindled to stellate cells with eosinophilic cytoplasm, perivascular hyalinization, interspersed with irregular myxoid regions. Additionally, isolated foci of odontogenic epithelium were noted. Immunohistochemical analysis demonstrated positive staining for CK AE1/3 and p63 in the epithelial component, while S100, SMA, desmin, and, notably, MUC4 were negative. A small number of cells were Ki-67 positive. The final diagnosis was odontogenic fibromyxoma with LGFS-like characteristics. As of a 3-year follow-up, there have been no recurrences or alterations. [ABSTRACT FROM AUTHOR] |
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