MANAGEMENT OF OSTEONECROSIS ASSOCIATED WITH THE USE OF ZOLEDRONIC ACID - CASE REPORT.

Autor: de PAULA, Bruna DALCOMUNI, PROHNY, João Paulo Stanislovicz, da SILVA, Priscila QUEIROZ Mattos, JUNIOR, Claudio FREIRE Sessenta, SASSI, Laurindo Moacir, SCHUSSEL, Juliana
Zdroj: Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology; Jun2024, Vol. 137 Issue 6, pe230-e230, 1p
Abstrakt: Bisphosphonates, commonly used for treating osteoporosis and cancer, have been associated with a complication known as jaw necrosis. We present the case of a 49-year-old female patient who was a smoker and had a history of Multiple Myeloma (MM). She complained of bone exposure in her mandible and severe localized pain, which coincided with a history of tooth extraction in the same area. The patient had previously undergone autologous hematopoietic stem cell transplantation (HSCT) for the treatment of MM and was receiving Zometa. Upon clinical examination, bone exposure in the region of tooth 46 was evident, accompanied by intense pain. A CT scan revealed a lytic area in the right posterior mandible measuring 19 mm, along with irregular thickening of the adjacent periosteum near the mandibular canal. MM lytic lesions were also observable. To address this, debridement of the necrotic bone was performed, and the site was covered with Bichat's ball. This procedure was carried out under general anesthesia due to the patient's neuralgic pain. The patient is currently under outpatient care and has experienced closure of the bone exposure. [ABSTRACT FROM AUTHOR]
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