| Abstrakt: |
A 77-year-old woman visited the Stomatology Department of a hospital, reporting a 90-day history of pain, burning, and swelling in her tongue. She had previously been diagnosed with breast cancer in 1992, which had metastasized to her lungs in 2015. At the time, she was receiving maintenance treatment with tamoxifen. An examination revealed a slight, palpable, posterior tongue enlargement. Amyloidosis, sarcoidosis, and metastasis were the primary diagnostic considerations. Subsequently, an incisional biopsy was conducted. The histopathological examination identified an undifferentiated tumor, which exhibited immunoreactivity for GATA-3, estrogen receptor, progesterone receptor, p16, cytokeratin AE1/AE3, and 34BE12 antibodies. The final diagnosis was determined to be breast cancer metastasis to the tongue. The patient was referred to clinical oncology, where she commenced treatment with fulvestrant, followed by a course of 45 Gy of intensity-modulated radiation therapy. It is imperative for clinicians to maintain a high level of suspicion for metastatic lesions when evaluating patients with a history of malignancy, even if there is a considerable time gap between the initial tumor diagnosis and the appearance of oral nodules. [ABSTRACT FROM AUTHOR] |
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