THE IMPORTANCE OF ORAL CAVITY SURVEILLANCE IN PATIENTS WITH FANCONI ANEMIA FOR EARLY DIAGNOSIS OF ORAL CANCER.

Autor: ROCHA, Paula Alves da Silva, SANTANA, Nayara Conceição Marcos, VENDRUSCOLO, Joana Letícia, PASCOAL, Thaís Pimenta, TORRES-PEREIRA, Cassius Carvalho, SILVA, Tarcília Aparecida
Zdroj: Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology; Jun2024, Vol. 137 Issue 6, pe165-e165, 1p
Abstrakt: Fanconi Anemia (FA) is a rare genetic disorder known for its bone marrow impact and increased cancer risk, particularly oral squamous cell carcinoma. In this case, a 36-year-old female patient with FA exhibited hypothenar facies, café-au-lait spots, pancytopenia, and multiple leukoplakias in the oral mucosa. Initial clinical examination revealed variable thickness white plaques on the hard and soft palate, leading to incisional biopsies and diagnoses of hyperkeratosis with mild and moderate epithelial dysplasia, respectively. After three months, new diffuse lesions emerged on the hard and soft palate, tongue, and buccal mucosa, accompanied by erythematous areas. Subsequent biopsies on the hard and soft palate confirmed severe and moderate epithelial dysplasia, respectively. This rapid transformation underscores the importance of closely monitoring FA patients to facilitate early detection of oral squamous cell carcinoma. [ABSTRACT FROM AUTHOR]
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