ORAL CANCER IN A PATIENT WITH FANCONI ANEMIA, 28 YEARS AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION: CASE REPORT.

Autor: VENDRUSCOLO, Joana Leticia, KOLODZIEJWSKI, Waleska Tychanowicz, TORRES-PEREIRA, Cassius Carvalho
Zdroj: Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology; Jun2024, Vol. 137 Issue 6, pe150-e150, 1p
Abstrakt: Patients with Fanconi Anemia (FA) have a higher risk of developing oral cancer, particularly after hematopoietic stem cell transplantation (HSCT). In this paper, we present the case of a 42-year-old female patient who underwent allogeneic HSCT from a sibling donor in 1995 and has been under monitoring of the same dental team for over ten years. This year, she received an anatomopathological exam after incisional biopsies, which revealed moderately differentiated squamous cell carcinoma on dorsum of the tongue and a region of moderate dysplasia on the lingual border. After the dysplastic area was removed using a high-potency laser, she was referred to the medical staff for tumor therapy. Constant examination by a specialized dental team is imperative for patients with AF, as HSCT conditioning therapies, such as chemotherapy and/or radiotherapy, can significantly contribute to malignant transformation, and this risk escalates over time. [ABSTRACT FROM AUTHOR]
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