| Autor: |
Finlayson, L., McMillan, L., Suveges, S., Steele, D., Eftimie, R., Trucu, D., Brown, C.T.A., Eadie, E., Hossain-Ibrahim, K., Wood, K. |
| Zdroj: |
Photodiagnosis & Photodynamic Therapy; Apr2024, Vol. 46, pN.PAG-N.PAG, 1p |
| Abstrakt: |
Glioblastoma is a deadly brain tumour with a low survival time. The INDYGO clinical trial aims to increase survival by maximizing tumour resection via PDT. A simulation of the trial protocol is independently produced with the aim of increasing understanding of the treatment parameters and their effect on treatment outcome. Monte Carlo Radiative Transport (MCRT) is used to simulate light travel and PDT within an in-silico brain model containing a glioblastoma. Treatment parameters were changed, and the effect determined based on the percentage of tumour killed. Simulating the standard trial setup with a 5 μM photosensitizer concentration resulted in 42 % cell kill by the end of treatment. Increasing treatment time and light power resulted in increased cell kill, however an increase in photosentisiser concentration had the biggest effect. These results provide detailed information that can be used when planning intraoperative PDT treatments for glioblastoma. [ABSTRACT FROM AUTHOR] |
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