| Autor: |
Hitomi ODA, Aiko HAGA, Kaoru KOYAMA, Kureha GOKITA, Ran AKIYAMA, Takumi KOMIYA, Shinogu HASEGAWA, Toshinori SAKO, Akihiro MORI |
| Předmět: |
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| Zdroj: |
Journal of Veterinary Medical Science; 2024, Vol. 86 Issue 4, p363-367, 5p |
| Abstrakt: |
Ezetimibe is a cholesterol absorption inhibitor that blocks the intestinal absorption of both biliary and dietary cholesterol, thereby lowering primarily low density lipoproteincholesterol (LDL-chol) in human studies. This study aimed to investigate the effects of ezetimibe on dyslipidemia control in nine dogs with hypercholesterolemia. Changes in total cholesterol (T-chol) and each lipoprotein fractions were evaluated at 0, 2, and 4 months following initiation of ezetimibe treatment. A significant decrease in T-chol was observed, and a mean T-chol concentration below 400 mg/dL was achieved at 2 and 4 months. Furthermore, a significant decrease in LDL-chol was observed (-53.3% and -64.3% at 2 and 4 months, respectively). Taken together, treatment of ezetimibe could lower LDL-chol levels in dogs with hypercholesterolemia. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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