Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist.

Autor: Balıkçı, Esra, Marques, Anne-Sophie M. C., Bauer, Ludwig G., Seupel, Raina, Bennett, James, Raux, Brigitt, Buchan, Karly, Simelis, Klemensas, Singh, Usha, Rogers, Catherine, Ward, Jennifer, Cheng, Carol, Szommer, Tamas, Schützenhofer, Kira, Elkins, Jonathan M., Sloman, David L., Ahel, Ivan, Fedorov, Oleg, Brennan, Paul E., Huber, Kilian V. M.
Zdroj: Journal of Medicinal Chemistry; 5/9/2024, Vol. 67 Issue 9, p7245-7259, 15p
Databáze: Supplemental Index