| Autor: |
Ruspita, Intan, Yunizar, Mohammad Fadyl, Aditama, Pramudya, Indrastuti, Murti, Barunawati, Sri Budi, Saleh, Suparyono, Listyarifah, Dyah |
| Předmět: |
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| Zdroj: |
Journal of International Dental & Medical Research; 2024, Vol. 17 Issue 1, p44-50, 7p |
| Abstrakt: |
This research aimed to develop alveolar bone regeneration that could restore its lost function in pre-prosthodontic treatment. Adult 3-month-old mice were made bone defect on the condyle femur bones. Gelatin scaffolds had been incubated with dental pulp stem cells (DPSCs) isolated from impacted tooth and were isolated into bone sockets along with platelet-rich fibrin (PRF) obtained from experimental animals. A histopathological examination was conducted to observe bone regeneration. The expression of genes Oct3/4 and Nanog as markers of proliferation and selfrenewal of stem cells showed abundant expression in isolated DPSCs. In histology, osteogenesis was more prominent in the treatment group compared to the control group. Collagen fibers were packed and more scattered over the defect area in the treatment group. The expression of BMP-2 was higher in the treatment group than in the control group. The application of DPSCs, gelatin scaffolds, and PRF had potential effect to stimulate bone formation. These materials might increase alveolar bone regeneration in pre-prosthodontic treatment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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