| Autor: |
Sosuke Yasunaga, Shumpei Fujie, Kenichiro Inoue, Eri Okumura, Toru Mizoguchi, Motoyuki Iemitsu |
| Zdroj: |
Advances in Exercise & Sports Physiology; Mar2024, Vol. 29 Issue 4, p78-78, 1/2p |
| Abstrakt: |
Purpose: This study aimed to clarify the combined effects of low-intensity resistance training and chlorella intake on vascular endothelial function in aged mice. Methods: In this study, 38-week-old male SAMP1 mice were divided into sedentary control (Con, N=7), low-intensity resistance training (LRT, N=8), and LRT and chlorella intake (CH) combined (LRT+CH, N=8) groups. LRT was performed 3 days a week for 12 weeks using a climbing ladder with 40% of 1 repetition maximum weight. The evaluation of vasodilation responses in aortic rings was measured using a wire myograph and expression of phospho-eNOS and total eNOS in aorta was measured using Western blotting. Results: Endothelium-dependent vasodilation response with acetylcholine and eNOS phosphorylation level were significantly higher in the LRT group compared to the Con group and were significantly higher in the LRT+CH group compared to the Con and LRT groups (each p<0.05). However, endothelium-independent vasodilation response with SNP did not differ among the three groups. Conclusion: These findings suggest that LRT combined with CH may further improve vascular endothelial function via the activation of eNOS phosphorylation in aged mice. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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