| Autor: |
Natale, Arianna, Turati, Federica, Taborelli, Martina, Giacosa, Attilio, Augustin, Livia S. A., Crispo, Anna, Negri, Eva, Rossi, Marta, La Vecchia, Carlo |
| Zdroj: |
Cancer Epidemiology, Biomarkers & Prevention; May2024, Vol. 33 Issue 5, p731-738, 8p |
| Abstrakt: |
Background: Diabetes has been associated with colorectal cancer. We evaluated whether adherence to a diabetes risk reduction diet (DRRD) can favorably influence the risk of colorectal cancer. Methods: Data came from a multicentric Italian case-control study including 1,953 histologically confirmed colorectal cancer cases and 4,154 hospital controls admitted for acute nonneoplastic diseases. Diet was assessed through a validated and reproducible food frequency questionnaire. The DRRD score was computed assigning higher values for higher consumption of cereal fiber, fruit, coffee, nuts and a higher polyunsaturated/saturated fats ratio and for lower glycemic index and lower consumption of red/processed meat and sweetened beverages and fruit juices. The ORs and the corresponding 95% confidence intervals (CI) of colorectal cancer according to the DRRD score were obtained using logistic regression models adjusting for total energy intake and other major confounders. Results: The DRRD was inversely related to colorectal cancer risk. The ORs of colorectal cancer were 0.77 (95% CI, 0.67-0.89) for the third versus first score tertile (Ptrend < 0.001) and 0.92 (95% CI, 0.87-0.96) for a 3-point increment in the score. Inverse associations were observed for colon and rectal cancers and were consistent in strata of sex, age, and other major covariates. Conclusions: A higher adherence to a DRRD was inversely associated with colorectal cancer risk. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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