Electro-generated base from amide derivative enables cyclopropanation of alkyl 2-chloroacetate without formation of trialkyl propane-1,2,3-carboxylate.

Autor: Kouichi Matsumoto, Mizuki Matsuse, Kengo Hamasaki, Hiyono Suzuki, Sora Okubo, Akane Togo, Yuuki Okayama, Norihito Kawashita
Zdroj: Chemistry Letters; Mar2024, Vol. 53 Issue 3, p1-4, 4p
Abstrakt: Electro-generated base was found to be quite effective for the formation of cyclopropane derivatives from alkyl 2-chloroacetates in good yields, without the formation of trialkyl propane-1,2,3-carboxylates of the inseparable by-product. The reaction optimization for electro-generated bases as well as scope and limitations were conducted for the current report. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index