| Autor: |
Hyung-Suk Yoon, Jie Wu, Shidal, Chris, Yan Sun, Franke, Adrian A., Jae Jeong Yang, Braithwaite, Dejana, Courtney, Regina, Hui Cai, Blot, William J., Xiao-Ou Shu, Wei Zheng, Qiuyin Cai |
| Zdroj: |
Cancer Epidemiology, Biomarkers & Prevention; Apr2024, Vol. 33 Issue 4, p480-488, 9p |
| Abstrakt: |
Background: Despite the various anticancer activities of tocopherols, little is known about tocopherols associated with lung cancer risk among low-income African Americans (AA) and European Americans (EA) who are disproportionately affected by the disease. Methods: We conducted a nested case-control study that included 209 incident lung cancer cases and 406 matched controls within the Southern Community Cohort Study. Using biospecimens collected at cohort enrollment, plasma levels of α-, β/γ-, δ-, and total-tocopherols were measured by high-performance liquid chromatography with photodiode array detection. Conditional logistic regression was used to estimate ORs and 95% confidence intervals (CI) for lung cancer risk after adjusting for potential confounders. Stratified analyses were also conducted. Results: Plasma levels of total-tocopherols were inversely associated with lung cancer risk overall [OR (95% CI) for the highest vs. lowest tertile = 0.51 (0.30-0.90)]. The inverse association remained significant among EAs [0.20 (0.06-0.65)], men [0.43 (0.21-0.90)], current smokers [0.49 (0.26-0.93)], and cases diagnosed within 2 years of blood draw [0.36 (0.15-0.86)], though we did not find a significant risk reduction among AAs [0.75 (0.39-1.45)]. Notably, we found significant interactions between α-tocopherol and race after controlling the FDR to correct for multiple comparisons (Pinteraction = 0.02). Conclusions: Our results indicate that plasma total-tocopherols are inversely associated with lung cancer risk, but the association may differ across specific isomeric forms of tocopherols, race, or other individuals' characteristics. Further large-scale studies are warranted to confirm our findings. Impact: Recommendations on tocopherols for lung cancer prevention should take isomers, race, and smoking behaviors into consideration.. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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