Antioxidant therapy for hepatic diseases: a double-edged sword.
| Autor: | Das, Sayandeep K., Nerune, Savitri M., Das, Kusal K. |
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| Předmět: |
THERAPEUTIC use of antioxidants
THERAPEUTIC use of vitamin E THERAPEUTIC use of vitamin C THERAPEUTIC use of minerals HEALTH literacy ENVIRONMENTAL health HEPATOTOXICOLOGY DISEASE management OXIDATIVE stress POLYPHARMACY LIVER diseases LIPID peroxidation (Biology) DRUG efficacy DNA damage DRUG interactions VIRUS diseases DISEASE susceptibility MITOCHONDRIAL pathology GENETICS DISEASE progression |
| Zdroj: | Journal of Basic & Clinical Physiology & Pharmacology; Jan2024, Vol. 35 Issue 1/2, p7-14, 8p |
| Abstrakt: | Liver diseases are complex conditions, significantly influenced by oxidative stress. This comprehensive review assesses the therapeutic role of antioxidants like l-ascorbic acid and α tocopherol, beta-carotene, various minerals, and plant-based ingredients in mitigating oxidative stress-induced liver diseases. The manuscript delves into the critical influence of genetic and epigenetic factors on disease susceptibility, progression, and response to antioxidant therapy. While animal studies suggest antioxidant efficacy in liver disease treatment, human trials remain inconclusive, and caution is advised due to its possible potential pro-oxidant effects. Moreover, the interactions of antioxidants with other drugs necessitate careful consideration in the management of polypharmacy in liver disease patients. The review underscores the need for further research to establish the clinical benefits of antioxidants with understanding of possible antioxidant toxicities to elucidate the intricate interplay of genetic, epigenetic, and environmental factors in liver diseases. The aim is to foster a better understanding of the knowledge on hepatic disease management with judicial antioxidant therapies. [ABSTRACT FROM AUTHOR] |
| Databáze: | Supplemental Index |
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