Borna disease in an adult free-ranging Eurasian beaver (Castor fiber albicus).

Autor: Ellenberger, Christin, Heenemann, Kristin, Vahlenkamp, Thomas W., Grothmann, Pierre, Herden, Christiane, Heinrich, Anja
Předmět:
Zdroj: Journal of Comparative Pathology; Feb2024, Vol. 209, p31-35, 5p
Abstrakt: Borna disease (BD) associated with a peracute bacterial septicaemia with Escherichia coli was diagnosed in an adult female, naturally infected, free-ranging Eurasian beaver of the subspecies Castor fiber albicus , clinically characterized by weight loss, depression, weakness and gurgled peristaltic sounds. The beaver was euthanized humanely. Necropsy and light microscopy revealed a non-purulent meningoencephalitis with typical mononuclear perivascular cuffs and parenchymal infiltrates. The diagnosis of BD was confirmed by detection of viral antigen and RNA by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). The PCR product was sequenced and cluster analysis revealed a close relationship between endemic clusters in Saxony-Anhalt. This is the first report of naturally occurring BD in a free-ranging Eurasian beaver. [ABSTRACT FROM AUTHOR]
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