Factors associated with pain pressure threshold in both local and remote sites in knee osteoarthritis.

Autor: Imamura, Marta, Rebello‐Sanchez, Ingrid, Parente, Joao, Marduy, Anna, Vasquez‐Avila, Karen, Pacheco‐Barrios, Kevin, Castelo‐Branco, Luis, Simis, Marcel, Battistella, Linamara, Fregni, Felipe
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Zdroj: PM & R: Journal of Injury, Function & Rehabilitation; Feb2024, Vol. 16 Issue 2, p132-140, 9p
Abstrakt: Background: Knee osteoarthritis (KOA) is a prevalent condition, and its most frequent symptom is pain that often leads to disability. Pain sensitization is a core feature of KOA, and it can be measured through quantitative sensory testing protocols such as pain pressure threshold (PPT). However, there is a lack of understanding about the factors that may influence changes in PPTs in the KOA population. Objective: To explore the clinical and functional factors associated with PPTs in a sample of people with chronic KOA pain and to compare models of local (knees) and remote (thenar regions) sites. Design: Cross‐sectional analysis of a prospective cohort. Setting: Primary care in public institution. Participants: 113 adults with KOA. Intervention: N/A. Main Outcome Measures: Multivariable regression analyses evaluating demographic, clinical, and functional variables that could be associated with local and remote PPTs (main outcomes) were performed. Results: Both thenar region (adjusted‐R2: 0.29) and knee (adjusted‐R2: 0.45) models had the same significant negative association with being a female, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain levels (thenar: β: −0.15, p =.002; knee: β: −0.2, p <.001), and the 10‐Meter Walking Test (thenar: β: −0.05, p =.038; knee: β: −0.08, p =.004). A small significant positive association with depressive symptoms was identified in both models, which acted as a confounder for WOMAC pain and was likely affected by unmeasured confounders. Conclusions: PPTs in KOA pain are associated with functional outcomes such as the 10‐Meter Walking Test and activity‐related pain intensity; thus more disability is associated with smaller pain thresholds. Similarity between models may suggest central sensitization. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index
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