Findings in Molecular Bioscience Reported from Amsterdam University Medical Center (The IRAK-M death domain: a tale of three surfaces).
| Zdroj: | Gene Therapy Weekly; 1/26/2024, p483-483, 1p |
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| Abstrakt: | A recent report from Amsterdam University Medical Center discusses the molecular bioscience of the anti-inflammatory interleukin-1 receptor associated kinase-M (IRAK-M). The research reveals that IRAK-M uses three surfaces of its Death Domain (DD) to activate NF-kB downstream of MyD88/IRAK-4/IRAK-M. The study also identifies the structure-function properties of IRAK-M, which could make it a potential therapeutic target for inflammatory diseases. This research was supported by Marie Curie. For more information, readers can contact the Center for Experimental and Molecular Medicine at Amsterdam University Medical Center. [Extracted from the article] |
| Databáze: | Supplemental Index |
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