| Autor: |
Jia, Weili, Jiang, Yong, Ma, Ruihua, Huang, Xinying, Gu, Hongqiu, Meng, Xia, Li, Hao, Zhao, Xingquan, Wang, Yilong, Wang, Yongjun, Li, Zixiao, Wang, Chunjuan |
| Zdroj: |
Journal of Stroke & Cerebrovascular Diseases; Jan2024, Vol. 33 Issue 1, pN.PAG-N.PAG, 1p |
| Abstrakt: |
To investigate the 10-year trend in healthcare quality of intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator in acute ischemic stroke (AIS) in China. We analyzed 42,188 AIS within 7 days of onset from the China National Stroke Registry (CNSR) Ⅰ-Ⅲ. Primary outcomes were temporal changes in the proportion of patients arriving at the hospital within 3.5 hours (and 2 hours) of onset and receiving IVT within 4.5 hours (and 3 hours), stratified by region and hospital tier. Secondary outcomes included temporal changes in door-to-needle time (DNT), DNT ≤60 min and favorable outcome defined as a 90-day modified Rankin Scale (mRS) of 0-1. Among patients arriving at the hospital within 3.5 hours of onset, 13.5%, 7.1% and 33.4% patients received IVT within 4.5 hours in CNSR Ⅰ, Ⅱ and Ⅲ, respectively, including a higher proportion from eastern China (37.0%) and tertiary hospitals (36.5%). The median DNT was shorter in CNSR Ⅲ (60.0 min) than those in Ⅱ (95.0 min) and I (94.0 min). The proportion of patients with DNT ≤60 min was greater in Ⅲ (53.4%) than those in Ⅱ (26.7%) and Ⅰ (13.4%). The proportion of favorable outcomes was higher in CNSR Ⅲ (72.8%) than those in Ⅱ (49.6%) and Ⅰ (49.4%). Similar trends were observed for patients arriving at the hospital within 2 hours and receiving IVT within 3 hours of onset. The healthcare quality of IVT has improved remarkably in the past decade, notably in eastern China and tertiary hospitals. [ABSTRACT FROM AUTHOR] |
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