| Autor: |
Lingegodwa, Abhishek Mensegere, Malo, Palash Kumar, Stezin, Albert, Hameed, Shafeeq K Shahul, Mallikarjun, Divya N, Partha, Ajith, M, Amitha C, Narayanasamy, Rajitha, R, Meghana, Menon, Meenakshi, Velavarajan, Goutham, Arvind, Prathima, HS, Sunitha, Singh, Sadhana, Kommaddi, Reddy Peera, Diwakar, Latha, Sundarakumar, Jonas S., Issac, Thomas Gregor |
| Zdroj: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 18, Vol. 19, p1-2, 2p |
| Abstrakt: |
Background: The burden of Cardiovascular risk factors is increasing in India and the rural population is more susceptible due to rapidly changing lifestyle. There cardiovascular risk factors are known to occur in clusters and are implicated in poor cognitive performance. The Framingham risk score (FRS) is a simplified and common tool for the assessment of risk of developing Cardiovascular events over 10 years using six risk factors, such as, age, gender, total cholesterol (TC), high density lipoprotein cholesterol (HDL), smoking habits, and systolic blood pressure. Srinivaspura Aging, Neuro Senescence and COGnition (SANSCOG) is a longitudinal, prospective cohort study in healthy aging individuals in a town located near Bangalore, India, where participants are recruited from the community. Method: Our objective was to examine to effect of FRS on cognitive performance measured by COGNITO among SANSCOG cohort participants. We performed separate multiple linear regression analysis to examine to effect of FRS on various COGNITO domains after adjusting for years of education and Geriatric Depression Scale (GDS) scores. Result: In a sample of 3929 individuals, 2022 (51.5%) were women. The median (IQR) age of the sample was 58 (50,65), the median (IQR) years of education was 4 (0,9) and the median (IQR) GDS was 2 (1,6). Multiple linear regression analysis was used to see the association of FRS with various cognitive tests after adjusting for years of education and GDS revealed that individuals with higher FRS performed poorly in all cognitive domains as shown in Table 1. When we examined this in men and women separately the results remained the same. Conclusion: We have demonstrated that higher FRS affects cognitive performance among rural elderly Indian individuals of both genders. It is imperative to design and implement strategies for risk‐reduction such as early identification and management of risk factors, a healthy lifestyle, balanced diet and regular physical exercise. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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