| Autor: |
Serrano‐Rubio, Luis Humberto, Young, Vanessa M., Velarde, Angel G., Gaona, Carlos A., Ramirez‐Castaneda, Juan, Horn, Sarah, Coss, Pablo, Vaou, Okeanis E., Saklad, Amy R., Shipp, Eric L., Seshadri, Sudha, Gonzalez, David A., Gonzales, Mitzi M. |
| Zdroj: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 18, Vol. 19, p1-3, 3p |
| Abstrakt: |
Background: Parkinson's disease (PD) is a neurodegenerative disorder affecting 1% of the global population. While the core clinical symptoms of PD are bradykinesia, rigidity, and tremor, it is also often accompanied by non‐motor symptoms that reduce quality of life and increase health care costs. Of the non‐motor symptoms in PD, hyposmia is one of the most prevalent and often precedes clinical diagnosis by several years. In addition, hyposmia has been associated with accelerated disease progression. As individuals with PD are at elevated risk for dementia, the goal of this pilot study was to objectively evaluate the association between smell sensitivity and cognition in early‐stage PD. Method: Participants with a clinical diagnosis of PD completed cognitive assessments of verbal and visual learning and memory, processing speed, attention, and executive function. Smell sensitivity was assessed using the University of Pennsylvania Smell Identification Test (UPSIT). Associations between cognitive performance and smell sensitivity were evaluated using partial correlations adjusting for age and education. Result: Nineteen participants (mean age 69.4+7.9, 25% female) with early‐stage Parkinson's disease (Hoehn and Yahr stage 1‐2) and free of dementia completed the UPSIT and cognitive assessments (see table 1 for sample characteristics). The average UPSIT score was 5.84+2.12 points and ranged from 2 to 10. Diminished olfactory sensitivity, assessed by the total correct score on the UPSIT, was associated with poorer visual learning (Brief Visual Memory Test Revised (BVMT‐R) immediate recall: r = 0.564, p = 0.18, Figure 1) and memory (BVMT‐R delayed recall: r = 0.610, p = 0.009, Figure 2). Conclusion: In the early‐stages of PD, diminished smell sensitivity was associated with poorer visual learning and memory, domains preferentially affected by the disease. The findings suggest that olfactory dysfunction may be a biomarker of cognitive decline. Larger, longitudinal studies will be important for evaluating the utility of olfactory function as a predictor of dementia risk in PD. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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