| Autor: |
Clark, Lindsay R., Chin, Nathaniel A., Erickson, Claire M, Johnson, Sterling C, Basche, Kristin E, Rosario, Hannah, Ketchum, Fred B |
| Zdroj: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 19, Vol. 19, p1-3, 3p |
| Abstrakt: |
Background: As biomarker testing becomes more widely available, people will have opportunities to learn Alzheimer's disease (AD) biomarker results. We developed an AD biomarker disclosure protocol to return amyloid PET results to participants interested in learning this risk‐related information. Our current objective was to evaluate the impact of returning biomarker results on longitudinal psychosocial outcomes. Method: 97 cognitively unimpaired older adults (mean age = 71.9 ± 4.8; 66% women; 29% amyloid+) were recruited from an observational cohort study. Participants completed questionnaires assessing concern about dementia, future time perspective, and cognitive complaints at baseline (pre‐disclosure) and after learning amyloid PET result (1‐ and 6‐months post‐disclosure). Participants completed measures of results‐related distress (Impact of Events Scale [IES]; Impact of Neuroimaging in AD [INI‐AD]) 1‐3 days after disclosure and then again at 1‐, 3‐, and 6‐months post‐disclosure. Linear mixed‐effects regression models were used to test for main effects of amyloid PET result and time (visit number), and an interaction of amyloid result x time on self‐reported outcomes. Result: Participants who learned amyloid PET results were elevated or non‐elevated had similar demographic characteristics (Table 1). A significant interaction between amyloid result x time was observed for concern about dementia (β = 0.30, p =.02), whereas future time perspective and cognitive complaints did not vary by result or time in study (main effect and interaction p's >.12; Table 2). Results‐related distress measures showed different patterns: A measure of intrusive thoughts and avoidance was initially high in elevated participants but decreased over time (IES; result x time interaction β = ‐0.83, p <.001), while a measure of psychosocial reactions to learning results was consistently high in elevated participants (INI‐AD; main effect of amyloid result β = 12.08, p <.001) (Figure 1). Conclusion: Older cognitively healthy adults who learned elevated amyloid PET results reported increased concern about dementia and results‐related distress compared to those who learned non‐elevated results. Although intrusive thoughts/avoidance decreased over time in elevated participants, results‐related distress remained high. These indicate some increased psychosocial impacts, and possible need for post‐disclosures support, for those who learn elevated biomarker results. [ABSTRACT FROM AUTHOR] |
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