| Autor: |
Unnam, Pavani P, Patel, Dhara S, Bhatt, Margi, McGinity, Sean, Botchway, Albert, Zec, Ronald F, Ala, Tom, Hascup, Erin R., Trivedi, Mehul Alkesh |
| Zdroj: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 19, Vol. 19, p1-2, 2p |
| Abstrakt: |
Background: The original Alzheimer's disease Assessment Scale (oADAS) has been used to measure cognitive aging in Alzheimer's disease (AD) since the 1980s and is considered the gold standard for assessing the efficacy of novel treatments for AD. However, the oADAS has been criticized for not being sensitive to predementia syndromes such as mild cognitive impairment (MCI) due to the ceiling effects of many of the ADAS subtests. In the present study, we used Exploratory Factor Analysis (EFA) to determine the underlying factor structure of the oADAS and a novel extended version of this measure (eADAS). Method: We included data from 978 participants who were enrolled in the SIU LCAS as controls. The majority of the cohort was White/Non‐Hispanic (97.2%) and female (66.4%). Participants had a mean age of 66.1 years and a mean education of 14.6 years. The oADAS was administered using standardized methods. All of the subtest data was converted back from error scores to raw scores and standardized using z‐score transformation. EFA with oblimin rotation was used. The sum of examiner ratings was excluded because it was the only measure not performance‐based. Result: For the oADAS, we identified two factors: A general factor (including 2 memory measures, naming, commands, and orientation) and a praxis factor (including constructional and ideational praxis). For the eADAS, we also identified two factors: A memory/speed factor (including 5 memory measures, orientation, word generation, and the letter‐digit test) and a general factor (including naming, constructional and ideational praxis, clock to command, and similarities). The commands subtest did not load onto either factor for the eADAS EFA. After controlling for education and sex, linear regression analysis confirmed previous findings that increasing age was associated with decreased factor scores (p < 0.001). Conclusion: The results of the present study provide novel information regarding the underlying factor structure of the oADAS and eADAS. Our results also confirm previous research demonstrating that increasing age is associated with reduced cognition after controlling for education and sex. Future directions include using these factor scores to examine the influence of risk factors for cognitive decline in predementia syndromes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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