| Autor: |
Carrasco‐Gómez, Martín, García‐Colomo, Alejandra, Nebreda, Alberto, de Frutos, Jaisalmer, Ramírez, Federico, Cabrera, Jesús, Fernández, Ricardo Bruña, Santos, Andrés, Maestú, Fernando |
| Zdroj: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 24, Vol. 19, p1-2, 2p |
| Abstrakt: |
Background: Alzheimer's disease (AD) is the most common cause of dementia. Although it presents a long preclinical period, treatment has yet to be found, and individuals at risk, like first‐degree relatives, are being studied to identify early detection markers to maximise the effectiveness of treatments. Functional connectivity changes have been observed even at this early stage (Ramirez‐Toraño et al., 2021), but most disregard its temporal dimension. This study investigates the value of a simple estimation of dynamic functional connectivity (dFC) in a longitudinal follow‐up of individuals with varying risk of the disease, as this parameter is expected to decrease across the disease continuum (Grieder et al, 2018). Method: 95 cognitively unimpaired participants with a family history of AD (FH+) and 39 without it (FH‐) underwent two longitudinal 5‐minute resting‐state magnetoencephalography recordings, approximately 3 years apart. FC in the low alpha band (8‐10 Hz) was estimated in 4‐second segments using phase locking value in the source space, and the standard deviation (STD) across epochs was calculated. Then, a STD ratio was derived dividing the STD values of the follow‐up session by those of the baseline session, and then averaged over nodes belonging to the same regions of the automatic anatomical labelling atlas. Left‐tailed t‐tests between the STD ratio of both groups in each ROI link (n_comparisons = 3160) were calculated and corrected for multiple comparisons with a false discovery rate using q = 0.20. Result: 13 links show a significantly lower dFC in the FH+ group than in the FH‐ group (Figure 1). Interestingly, these links involve regions where amyloid‐beta deposits early in the AD continuum (Mattsson et al., 2019), and are strongly related to the default mode network (Palmqvist et al. 2017). Conclusion: This study suggests that a simple estimation of dFC like STD may be useful in early detection pathological patterns characteristic of AD, even in cognitively unimpaired individuals at risk. The fact that dFC decreases were detected in areas where amyloid deposits appear at an early stage might indicate that these changes are related to changes in the excitation/inhibition ratio, which will be further studied in upcoming investigations. [ABSTRACT FROM AUTHOR] |
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