| Autor: |
Anzai, Juliana A. U., Christiano, Caitlyn, Moreno, Stephanie, Viera, Andrea M Román, Kirn, Dylan, Papp, Kathryn V., Chhatwal, Jasmeer P., Johnson, Keith A., Rentz, Dorene M., Selkoe, Dennis J, Sperling, Reisa A., Amariglio, Rebecca E., Yang, Hyun‐Sik |
| Zdroj: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 24, Vol. 19, p1-2, 2p |
| Abstrakt: |
Background: A brief self‐reported questionnaire to efficiently capture subjective cognitive decline, a stage considered to be between cognitively unimpaired and mild cognitive impairment, could enhance clinical research and practice. We hypothesized that a 3‐question measure of self‐reported cognitive decline is associated with worse cognitive performance and increased functional changes reported by a study partner (SP). Method: The Davis Memory and Aging Cohort (MAC) at Mass General Brigham recruits individuals 45 years or older with a broad range of cognitive symptoms. Participants answered the following three questions adapted from the NIA‐AA research framework: Q1. "Have you experienced a change in your memory in the last 1‐3 years?" Q2. "Has this been a persistent change over the last 6 months?" Q3. "Are you concerned about this change?" scored on a Likert scale (0‐4), with high scores representing greater decline. Responses to Q2 and Q3 were set to 0 if Q1 = 0. Participants completed the Mini‐Mental State Examination (MMSE; cognitive performance), and SPs completed the Quick Dementia Rating System (QDRS; functional changes). We tested the association between the total BCSS score (Q1+Q2+Q3; predictor) and MMSE or QDRS total scores (outcome) using linear regression controlling for age, sex, and years of education. We then tested these associations in a subgroup without significant SP concern (QDRS<1.5). Result: There were 399 MAC participants with complete data (mean age = 67.2±8.3, 64% female, Table 1). Based on QDRS cut‐offs, there were 248 cognitively unimpaired participants, 118 with mild cognitive impairment, and 33 with dementia. The total score was associated with lower MMSE (beta = ‐0.30, p<0.001) and higher QDRS (beta = 0.51, p<0.001). Q1 score by itself was associated with lower MMSE (beta = 0.98, p<0.001) and higher QDRS (beta = 1.2, p<0.001) (Figure 1). In a subset with QDRS<1.5 (n = 248), both the total score (beta = ‐0.22, p = 0.002) and Q1 score (beta = ‐0.62, p<0.001) were associated with lower MMSE. Conclusion: Self‐reported cognitive decline was associated with worse global cognition, even among those whose SPs reported no significant functional concerns. Our results suggest that the brief self‐reported questionnaire could be a useful screening tool in research and clinic that efficiently probes cognitive functioning. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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