| Autor: |
Hosseini, Seyyed Ali, Servaes, Stijn, Therriault, Joseph, Tissot, Cécile, Rahmouni, Nesrine, Macedo, Arthur C., Lussier, Firoza Z, Stevenson, Jenna, Wang, Yi‐Ting, Arias, Jaime Fernandez, Aumont, Etienne, Socualaya, Kely Quispialaya, Nazneen, Tahnia, Stevenson, Alyssa, Gauthier, Serge, Pascoal, Tharick A., Rosa‐Neto, Pedro |
| Zdroj: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 17, Vol. 19, p1-3, 3p |
| Abstrakt: |
Background: Different methods have been proposed to assess vascular dysfunction in Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively unimpaired (CU) subjects including quantitative susceptibility mapping (QSM), and recently oxygen extraction fraction (OEF). QSM is sensitive to the presence of iron and is a non‐invasive MR approach to measure local tissue susceptibility with high spatial resolution. OEF is a measure of the percentage of oxygen taken from the brain's blood supply and relates directly to brain oxygen metabolism. Here, we aimed to examine QSM (Figure1) and OEF (Figure1) potential in differentiating AD, MCI, and CU. Method: A cohort of 310 subjects with AD (n = 48), MCI (n = 80), and CU (n = 182) were recruited. All the patients received 3D gradient‐recalled echo sequence MRI. All QSM images were constructed by MEDI+0 and OEF images were constructed by QSM+qBOLD model with CCTV (Temporal clustering, tissue composition, and total variation). Eighty‐two various brain regions of interest (ROI) and 6 Braak ROI were investigated in the current study. ANOVA and Posthoc least significant difference (LSD) tests were implemented for each ROI over AD, MCI, and CU. Result: Over Braak ROI analysis, the ANOVA test showed that the average susceptibility of QSM with Braak 4 ROI is significantly different (p<0.001). LSD test showed that Braak 4 ROI of QSM is significantly different between AD vs. MCI and AD vs. CU (p<0.001). Braak 2 ROI of OEF was significantly different between AD vs. MCI and AD vs. CU (p = 0.21 and p = 0.32, respectively). Over brain ROI, the ANOVA test showed QSM right and left posterior cingulate and right Caudate were significantly different (p<0.001). Besides, these ROIs were significantly different between AD vs. MCI and AD vs. CU, according to the LSD test. Over brain ROI, OEF right Caudate was significantly different (p<0.001) followed by left Caudate and Right transverse temporal with p = 0.002 based on the ANOVA test. However, right and left Caudate were just significantly different between AD vs. CU (p<0.001) based on the LSD test (Table 1 and 2). Conclusion: QSM and OEF are affordable non‐invasive MR approaches to assess vascular dysfunction in the spectrum of clinical presentations of AD. [ABSTRACT FROM AUTHOR] |
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