| Autor: |
Tang, Jianing, Pahlavian, Soroush Heidari, Joe, Elizabeth B, Terner, Jamie, Braskie, Meredith N, Marmarelis, Vasilis, Chui, Helena C, Yan, Lirong |
| Zdroj: |
Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 17, Vol. 19, p1-3, 3p |
| Abstrakt: |
Background: Previous studies have indicated that arterial stiffness could play an important role in the AD pathology. Arterial stiffness is typically measured by pulse wave velocity (PWV) from central and peripheral arteries. Recent work has introduced a two‐minute robust MRI method to measure carotid PWV (cPWV) using a single‐slice oblique‐sagittal phase‐contrast MRI(OS PC‐MRI)[Pahlavian SH et al, JCBFM 2021]. This study aims to evaluate cPWV measured by OS PC‐MRI as a sensitive imaging marker of AD by studying the association of cPWV with cognitive performance and amyloid pathology. Method: Twenty‐three elderly volunteers (13 female, 72.6 ± 7.1 years) participated in the study and underwent cognitive and functional assessments including Clinical Dementia Rating (CDR, n = 23), Mini‐Mental State Exam (MMSE, n = 21), and Montreal Cognitive Assessment (MoCA, n = 23) and F18‐florbetaben amyloid‐PET scans (n = 14). A retrospectively gated single‐slice 2D OS PC‐MRI was performed on each participant at 3T to assess cPWV. The correlations between cPWV vs cognitive measures and cerebral amyloid were calculated across subjects using Pearson or Spearman's correlation coefficients. Result: Table 1 lists the demographic and clinical information of participants. cPWV showed significant negative correlations with both MoCA (Figure 1a) and MMSE (Figure 1b) (cPWV vs. MoCA: r = ‐0.57, p = 0.0044; cPWV vs. MMSE: r = ‐0.74, p < 0.001;), and correlations remained significant after controlling for age, gender, years of education (cPWV vs. MoCA:r = ‐0.70, p < 0.001; cPWV vs. MMSE: r = ‐0.75, p < 0.001). Participants were further separated into two groups (CRD = 0: n = 12; CDR> = 0.5: n = 11) based on their CDR scores. cPWV values were significantly higher in the group with CDR> = 0.5 without and with correcting for age, sex, and educational level (p = 0.0019, p = 0.015) (Figure 1c). Individuals who presented with amyloid pathology had higher cPWV compared to the ones without amyloid pathology (p = 0.038) (Figure 2), which indicates cPWV may be closely linked to amyloid pathology in AD. Conclusion: This study demonstrates that elevated carotid PWV is associated with cognitive impairment and amyloid pathology in elderly adults. Longitudinal studies are necessary to determine whether cPWV contributes to accumulation of amyloid in brain parenchyma or results from deposition of amyloid in cerebral blood vessels. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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