| Abstrakt: |
A recent report from the Chan Soon-Shiong Institute of Molecular Medicine at Windber in Pennsylvania explores the association of clinicopathologic and molecular factors with the occurrence of positive margins after the first surgery in breast cancer. The study analyzed clinical and RNA-Seq data from 951 primary breast cancer patients and found that higher stage, larger tumor size, positive lymph nodes, and presence of distant metastasis were significantly associated with positive surgical margins. Lumpectomy was also found to be more likely to result in positive margins compared to mastectomy. The study also identified potential genes and pathways that could predict positive margin status. Further research is needed to validate these findings. [Extracted from the article] |
