| Autor: |
Nanas, John N., Kralios, Alexandros C. |
| Zdroj: |
Journal of Electrophysiology; Dec1988, Vol. 2 Issue 6, p455-460, 6p |
| Abstrakt: |
The article focuses on a study related to the coronary blood flow and ventricular fibrillation threshold in beta-blocked dogs with stabilized hemodynamics. Several clinical trials have shown that long-term therapy with a beta adrenergic blocking drug after acute myocardial infarction can reduce overall mortality and particularly sudden cardiac death. Five healthy adult Mongrel dogs of either sex weighing between 20 and 25 kilograms were anesthetized with intravenous chloralose. This study examined the effects of timolol on vulnerability to ventricular fibrillation in comparison with LV function indices and coronary blood flow in a hemodynamically stabilized preparation. It appears that the antifibrillatory effect of beta-blockade with timolol is present despite depressed LV function. |
| Databáze: |
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