Preparation of sn-2-acTAG from Polygala seed oil and a study on its hypolipidemic effect.

Autor: Wang, Qing, Huang, Chen, Zhang, Meng-Qi, Rong, Yao, Guo, Xu, Smith, Mark A., Liu, Chao, Sun, Jin-Yue
Zdroj: Journal of Functional Foods; Dec2023, Vol. 111, pN.PAG-N.PAG, 1p
Abstrakt: [Display omitted] • Sn -2-acTAG was prepared and purified from Polygala seed oil. • A diet containing 20% sn -2-acTAG or lower was not toxic to SD rats. • Sn -2-acTAG could regulate the expression of proinflammatory factors. • Sn -2-acTAG could prevent and treat hyperlipidemia in the model rat. A new class of 2-acetyl-1,3-diacyl- sn -glycerols (sn -2-acTAG) was found in the seed oil of Polygala previously. Its structure is very similar to sn -1,3-DAG, which has effect of preventing and treating hyperlipidemia and other diseases. In this study, sn -2-acTAG was enriched and confirmed, the safety and the hypolipidemic activity was assessed. In addition the mechanism of action was investigated. Our study indicated that a diet containing 20% sn -2-acTAG or lower was not toxic to SD rats. Compared to the soybean oil group, sn -2-acTAG could lower the total cholesterol, triglyceride, and high-density lipoprotein cholesterol levels, as well as rise the level of high-density lipoprotein cholesterol. Sn -2-acTAG could regulate the expression of proinflammatory factors to ameliorate hyperlipidemia. In conclusion, sn -2-acTAG has for the first time been found to significantly ameliorate hyperlipidemia in the high-fat diet rat. This study will provide a strong theoretical support for the efficient development and application of Polygala seed oil. [ABSTRACT FROM AUTHOR]
Databáze: Supplemental Index
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