| Autor: |
NIE, Jinchun, MEI, Fang, ZHENG, Yueyuan, WEN, Qiuyi, LI, Zhenwei, ZHANG, Daidi, LI, Wei, GUO, Dean |
| Zdroj: |
Chinese Journal of Natural Medicines; Nov2023, Vol. 21 Issue 11, p859-867, 9p |
| Abstrakt: |
Five new racemic N -acetyldopamine (NADA) trimers, asponchimides A−E (1 − 5), were isolated from Aspongopus chinensis , a prominent traditional Chinese medicinal insect employed for alleviating pain, treating indigestion, and addressing kidney ailments. Compounds 1 − 5 were successfully resolved by chiral high-performance liquid chromatography (HPLC), yielding five pairs of enantiomers: (+)- and (−)-asponchimides A−E (1a / 1b − 5a / 5b). Their structural identities were discerned by extensive spectroscopic analyses, including high-resolution mass spectrometry (HRMS), ultraviolet-visible (UV-Vis) spectroscopy, infrared (IR) spectroscopy, and nuclear magnetic resonance (NMR), and their absolute configurations were determined by electronic circular dichroism (ECD) calculations. Compounds 1 − 5 are pioneering instances of NADA trimers featuring a Δ7 double bond. When subjected to a series of bioassays, a majority of the compounds exhibited weak inhibitory activity against nitric oxide (NO) production in LPS-induced RAW 264.7 cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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