Structural integrity of grey and white matter in schizophrenic patients by diffusion tensor imaging.

Autor:	Khalil, Aya Mohamed Reda, Samier, Heba Mohamed, Dawoud, Mahmoud Abdelaziz, Elsharawy, Fatma Anas
Předmět:	GRAY matter (Nerve tissue) BRAIN STATISTICS SCHIZOPHRENIA MAGNETIC resonance imaging CASE-control method MANN Whitney U Test FISHER exact test WHITE matter (Nerve tissue) PEARSON correlation (Statistics) DESCRIPTIVE statistics CHI-squared test DATA analysis software DATA analysis RECEIVER operating characteristic curves LONGITUDINAL method
Zdroj:	Egyptian Journal of Radiology & Nuclear Medicine; 11/21/2023, Vol. 54 Issue 1, p1-14, 14p
Abstrakt:	Background: Schizophrenia is a chronic disabling mental illness. A novel magnetic resonance imaging (MRI) technique known as diffusion tensor imaging (DTI) is a non-invasive and does not need external contrast materials. It is capable of identifying anomalies in the white matter micro-structure of the brain. This work conducted the DTI in schizophrenic patients to evaluate altered structural integrity in grey and white matter. Methods: This prospective case control study was conducted on 25 schizophrenic patients selected from neuropsychiatric department, and 25 age/sex-matched healthy controls. Results: Schizophrenic patients showed diminished fractional anisotropy in fornix, corpus callosum, right cingulum, right superior and inferior occipito-frontal fasciculi. Increased mean diffusivity in right inferior occipito-frontal fasciculus, corpus callosum, right thalamus and right basal ganglia were noted in schizophrenic patients. Fractional anisotropy and mean diffusivity had a predictive value for detection of schizophrenic patients. Conclusions: DTI of white and grey matter tracts is considered a promising tool for diagnosis of schizophrenic patients which usually have prolonged illness, chronic course and poor outcome. [ABSTRACT FROM AUTHOR]
Databáze:	Supplemental Index
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