| Autor: |
Masahiro SHINADA, Daiki KATO, Masaya TSUBOI, Namiko IKEDA, Susumu AOKI, Takaaki IGUCHI, Toshio LI, Yuka KODERA, Ryosuke OTA, Shoma KOSEKI, Hayato SHIBAHARA, Yosuke TAKAHASHI, Yuko HASHIMOTO, CHAMBERS, James K., Kazuyuki UCHIDA, Shunsuke NOGUCHI, Yukinari KATO, Ryohei NISHIMURA, Takayuki NAKAGAWA |
| Předmět: |
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| Zdroj: |
Journal of Veterinary Medical Science; 2023, Vol. 85 Issue 10, p1068-1073, 6p |
| Abstrakt: |
Podoplanin (PDPN) is a prognostic factor and is involved in several mechanisms of tumor progression in human squamous cell carcinoma (SCC). Canine non-tonsillar SCC (NTSCC) is a common oral tumor in dogs and has a highly invasive characteristic. In this study, we investigated the function of PDPN in canine NTSCC. In canine NTSCC clinical samples, PDPN overexpression was observed in 80% of dogs with NTSCC, and PDPN expression was related to ki67 expression. In PDPN knocked-out canine NTSCC cells, cell proliferation, cancer stemness, and migration were suppressed. As the mechanism of PDPN-mediated cell proliferation, PDPN knocked-out induced apoptosis and G2/M cell cycle arrest in canine NTSCC cells. These findings suggest that PDPN promotes tumor malignancies and may be a novel biomarker and therapeutic target for canine NTSCC. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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