| Autor: |
Ledón, Nuris, Añé-Kourí, Ana Laura, Ramos, Mercedes Bárbara, Lorenzo-Luaces, Patricia, Silva, Alexa, Pereira, Karla, Lage, Agustin, Saavedra, Danay |
| Zdroj: |
Aging Clinical & Experimental Research; Nov2023, Vol. 35 Issue 11, p2839-2842, 4p |
| Abstrakt: |
Centenarians are the best example of successful aging in humans. This work aimed to understand if immune status is associated with survival in Cuban centenarians. In a previous study, our group enrolled 43 centenarians and evaluated their immune status and functional capacity. 41 out of 43 recruited centenarians received follow-up phone calls, during a period of 2 years. Absolute CD4 + T cell count was higher among survivors, while the frequency of CD8 + CCR7-CD45RA + , CD8 + CD45RA + CD28-, and CD4 + CD28- T cells was higher among non-survivors. We also found that higher frequencies of terminally differentiated T cells were related to a higher risk of death, while centenarians with higher frequencies of T cells were more likely to survive. Surprisingly, neither serum inflammatory markers nor frailty/dependency was associated with survival. Our preliminary study suggests that immuno-senescence markers, but not inflammaging or functional capacity, are associated with survival beyond 100 years in a small group of Cuban centenarians. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full text from SpringerLink