| Autor: |
Cavalcante, Malena Gadelha, Gomes, Pedro Eduardo Andrade de Carvalho, Parente, Matheus de Sá Roriz, Meneses, Gdayllon Cavalcante, Silva Junior, Geraldo Bezerra da, Neto, Roberto da Justa Pires, Martins, Alice Maria Costa, Daher, Elizabeth De Francesco |
| Zdroj: |
AIDS Research & Human Retroviruses; Sep2023, Vol. 39 Issue 9, p468-474, 7p |
| Abstrakt: |
This study aimed to investigate the association between novel biomarkers and renal injury in people with HIV (PWH). A cohort study was carried out with PWH under chronic use of antiretroviral therapy (ART), followed at a public outpatient service. Clinical and laboratory parameters of the patients were evaluated year by year, from 2015 [at baseline (year 1, Y1)] to 2019 [year 5 (Y5)]. At baseline, biomarkers of renal damage (e.g., neutrophil gelatinase-associated lipocalin—NGAL, monocyte chemoattractant protein-1—MCP-1, and kidney injury molecule-1—KIM-1) and endothelial activation or glycocalyx damage [e.g., intercellular adhesion molecule 1 (ICAM-1), E-selectin, and syndecan-1] were quantified using enzyme-linked immunosorbent assays and their levels were used to classify patients into different groups. However, only syndecan-1 showed a significant correlation with serum creatinine (p < .001) and glomerular filtration rate (GFR) (p = .003) over the years. Moreover, both serum creatinine and GFR in almost 5 years were significantly associated with serum levels of syndecan-1 at baseline. The multivariate linear regression with confounders showed a significant and independent association between GFR and levels of syndecan-1 and CD4 cell count in the beginning of the study, as well as age in Y5. The data reinforce the screening for kidney diseases with novel biomarkers, especially syndecan-1, as an important strategy for a timely diagnostic and therapeutic approach. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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