Relation between morphological features of initial breast MRI and breast cancer molecular subtypes.

Autor:	Temerik, Safaa Mohammed, Elwahab, Saeda Mohamed Abd, Wahman, Mohammed Mostafa, Ahmed, Mohammed Youssef, Elwanis, Mostafa Elsayed Abd
Předmět:	BREAST cancer prognosis BREAST tumor diagnosis RESEARCH SCIENTIFIC observation BIOPSY CROSS-sectional method MAGNETIC resonance imaging MOLECULAR pathology RETROSPECTIVE studies CELL receptors TREATMENT effectiveness DESCRIPTIVE statistics CHI-squared test DECISION making in clinical medicine STATISTICAL correlation DATA analysis software MOLECULAR structure BREAST tumors HORMONE receptor positive breast cancer
Zdroj:	Egyptian Journal of Radiology & Nuclear Medicine; 9/5/2023, Vol. 54 Issue 1, p1-11, 11p
Abstrakt:	Background: Because different gene receptors might cause each case of breast cancer, the disease is classified as a heterogeneous form because it can be subdivided into molecular subtypes. These molecular subtypes are different in disease manifestation, therapeutic response, and prognosis. Magnetic resonance imaging (MRI) has many applications in breast cancer's initial diagnosis and assessment of treatment response. The purpose of this research was to determine whether or not there is a correlation between specific morphological aspects of breast MRI in breast cancer and specific breast cancer subtypes and their impact on treatment decisions. Results: There was an insignificant difference between different mass shapes and different molecular subtypes (P > 0.05). One hundred percent of triple-negative breast cancers (TNBC) were rounded. Molecular subtypes and the spiculated mass border diverged significantly statistically (P = 0.023). The percentage of the hormonal receptor (HR)-positive breast cancers with a spiculated border (80%) was greater than TNBC (0%) and distinctively different (P = 0.044). Surgical alternatives were observed to correlate significantly with the MRI mass border type (P = 0.030). There was an insignificant difference between molecular subtypes and tumor size (P = 0.602), lymph nodes (P = 0.283), multicentricity (P = 0.386), and curve type (P = 0.107). Conclusions: MRI breast imaging has an important role in diagnostic and prognostic settings. The morphological results of MRI can be a helpful tool in distinguishing between the various subtypes of breast cancer. There was a statistically significant difference between different molecular subtypes and the spiculated mass border (P = 0.023). There was a statistically significant difference between the type of breast cancer surgery and the mass border (P = 0.030). [ABSTRACT FROM AUTHOR]
Databáze:	Supplemental Index
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