Evaluating Serum Proteome in Women with Obsessive-Compulsive Disorder/Bipolar Disorder Compared to Pure Obsessive- Compulsive Disorder Subjects and Healthy Controls.
| Autor: | TAHERY, Noorollah, REZAEI TAVIRANI, Mostafa, ZAMANIAN AZODI, Mona, HAMDIEH, Mostafa, ROSTAMI NEJAD, Mohammad, MAHMOODI, Nahid |
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| Předmět: |
BLOOD serum analysis
DIAGNOSIS of obsessive-compulsive disorder DIAGNOSIS of bipolar disorder PROTEINS BIOMARKERS BLOOD proteins ELECTROPHORESIS PROTEOMICS VITAMIN D COMPARATIVE studies PSYCHOLOGY of women MASS spectrometry DESCRIPTIVE statistics GLOBULINS OBSESSIVE-compulsive disorder BIPOLAR disorder CARRIER proteins |
| Zdroj: | Iranian Journal of Child Neurology; Summer2023, Vol. 17 Issue 3, p133-142, 10p |
| Abstrakt: | Objectives The present study aimed to evaluate the serum proteome of women with obsessive-compulsive disorder (OCD)/bipolar disorder (BP) compared to pure OCD subjects and healthy controls. Materials & Methods Serum proteome of women with OCD/BP, pure OCD individuals, and healthy controls were subjected to 2DE-based proteomics accompanied with MALDI-TOF-TOF mass spectrometry. Further evaluation of the identified protein spots with the significance of p<0.05 and fold≥1.5 was done by applying protein interaction mapping via Cytoscape v. 5.3.1 and its plugins. Results The results indicate that vitamin D binding protein (GC) and haptoglobin spots (HP) significantly changed expression in OCD and OCD/BP with different expression patterns. These identified spots may contribute to OCD/BP and act as differentially recognized biomarkers comparing pure OCD and OCD/BP. Conclusion The Findings imply that these proteins in the serum of the patients could be potential distinguishable biomarkers in clinical usage after related validation experiments. Therefore, this study provides a preliminary evaluation to understand OCD/BP proteome behavior better. [ABSTRACT FROM AUTHOR] |
| Databáze: | Supplemental Index |
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