Study of pre-operative neutrophil–lymphocyte ratio in urothelial carcinoma.
| Autor: | Sahu, Kausalya Kumari, Ramineni, Madhurya, Suresh, Pooja K., Kini, Jyoti R., Lobo, Flora D. |
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| Předmět: |
BLADDER tumors
DISEASE progression STATISTICS PREOPERATIVE period CYSTOSCOPY MULTIVARIATE analysis RETROSPECTIVE studies ACQUISITION of data CANCER relapse FISHER exact test NEUTROPHIL lymphocyte ratio TRANSITIONAL cell carcinoma RISK assessment CANCER patients TUMOR classification SURVIVAL analysis (Biometry) MEDICAL records KAPLAN-Meier estimator CHI-squared test DESCRIPTIVE statistics TUMOR markers PROGRESSION-free survival BLOOD cell count CYTOLOGY URINALYSIS DATA analysis software LOGISTIC regression analysis PREDICTION models TUMOR grading PROPORTIONAL hazards models |
| Zdroj: | Journal of Basic & Clinical Physiology & Pharmacology; Jul2023, Vol. 34 Issue 4, p459-464, 6p |
| Abstrakt: | Neutrophil–lymphocyte ratio (NLR), as an indicator of heightened systemic inflammatory response, predicts increased disease burden and poor oncological outcomes in urothelial carcinoma (UC). The study was undertaken with an aim to evaluate the association of NLR with clinicopathological variables and survival outcomes. A total of 80 patients of UC were enrolled in the current retrospective study. Pre-operative NLR (within one month prior to the procedure), patient age, sex, tumour grade, pathological stage, recurrence free survival (RFS), progression free survival (PFS) and cancer specific survival (CSS) were recorded. We chose a cut-off value of 2.7 for NLR and patients were divide into two groups (NLR <2.7 and ≥2.7). NLR ≥2.7 was significantly associated with advanced tumour stage (p=0.001), but not with tumour grade (p=0.116). Progression (p=0.032) and death rates (p=0.026) were high in patients with NLR ≥2.7. Mean RFS (p=0.03), PFS (p=0.04) and CSS (p=0.04) were reduced in patients with NLR ≥2.7. On univariate analysis, NLR ≥2.7 predicted worse RFS (HR=2.928, p=0.007), PFS (HR=3.180, p=0.006) and CSS (HR=3.109, p=0.016). However, it was not an independent predictor of outcomes on multivariate analysis. Tumour stage and grade are the only independent predictors of RFS, PFS and CSS. High NLR at a cut-off value of ≥2.7 is associated with advanced pathological stage, but does not have an independent predictive value for RFS, PFS and CSS. [ABSTRACT FROM AUTHOR] |
| Databáze: | Supplemental Index |
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