| Abstrakt: |
Aim: Chronic wounds are difficult to heal with conventional treatments. The patients' profile who better benefit from autologous platelet-rich plasma (PRP) therapy is not clear. This study is focused on the identification of influential variables in the success of this therapy to analyze the personalized-therapeutical potential of PRP for treating chronic wounds. Method: Observational pilot study in patients with chronic wounds treated with autologous PRP. We analyzed socio-demographic data, etiology, clinical and analytical parameters, healing rate and healing time. Data were analyzed using descriptive statistics, principal component analysis (PCA), cluster analysis and survival analysis. Results/Discussion: The study included 56 patients (33 women, mean age 75.07±14.7), of whom 55% have mild and moderate frailty (VIG index: 0.16-0.35). Wound etiologies: 20% venous, 18% suture dehiscence, 12% pressure ulcers, 12% traumatic, 9% diabetics, 9% arterial, and 20% others. The mean wound size was 17.65 cm2. Higher healing rate was observed in patients with lower VIG and in wounds < 10 cm2. A total of 3 patients' clusters have been identified according to their analytical parameters. Cluster patients with high values of erythrocytes, hemoglobin, hematocrit, platelets, and albumin showed the highest healing rate. The survival analysis showed: a) 15% of ulcers healed at 5 weeks, 55% at 10 weeks, and 79% at 15 weeks; and b) patients with wound size < 4cm2 or VIG < 0.35 had the lowest healing time. Conclusion: PRP therapy success depends on wound size, patients' frailty, and analytical parameters, suggesting that personalization of PRP therapy might be recommended. [ABSTRACT FROM AUTHOR] |
