| Autor: |
Diaz, Maria Ines, Ramirez, Claudia, Rojas-Mancilla, Edgardo, Avila, Giselle |
| Předmět: |
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| Zdroj: |
Journal of Wound Management; Jul2023, Vol. 24 Issue 2, p118-118, 1/3p |
| Abstrakt: |
Aim: Over the last decade the rate of amputations due to diabetic foot ulcers (DFU) has increased by 28% and will continue increasing as diabetes does too. Despite the wide variety of products to treat them, it is still an unsolved problem, allowing the exploration of new solutions. Thus, the objective of our project is to evaluate the effectiveness of a gel made from natural active ingredients and supplemented with copper nanoparticles in the treatment of DFU. Method: Twenty patients were recruited for the study, following these criteria: patients diagnosed with diabetes permanently monitored at the health center, with a first-time or single recurrence wound. Subsequently, after a signed an informed consent form the product was applied according to the instructions of the health personnel, followed up for 4 weeks. Photographic record and a drawing of the wound were obtained to determine the wound area. In some cases, proinflammatory interleukins were measured. Results / Discussion: The average age of the treated patients was 60.2 years and 53% of them were women. The patients had an average of 14 years with diabetes. After four weeks product application it was observed that in most of the treated patients (90%), the wound area was reduced around 80%. Also, a reduction on proinflammatory interleukins was observed. Conclusion: This preliminary pilot study shows promising results of the use of copper nanoparticles in reducing the area of DFUs. Patients with less reduction in wound area had deeper wounds and required 3-4 more weeks of product application. Further study is required to understand the cellular pathways involved in these results. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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