| Autor: |
Bosque, Brandon, Kaufman, Richard, Melin, Mark, Zilberman, Igor, Zolfaghari, Nooshin, Geiger, James, Longobardi, James, Que, Howie, Skurka, Joseph, Dowling, Shane, May, Barnaby |
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| Zdroj: |
Journal of Wound Management; Jul2023, Vol. 24 Issue 2, p66-66, 1/2p |
| Abstrakt: |
Aim: The aim of this study was to evaluate the safety and efficacy of ovine forestomach matrix scaffold (OFM) in the management of complex, contaminated lower limb wounds by facilitating rapid build tissue and provide cover to exposed structures with viable granulation, ultimately shortening the time to definitive closure. Method: This retrospective, institutional review board (IRB)-approved study of 50 case records were evaluated (n=50) across seven (7) healthcare centers across the United States to identify patient co-morbidities, defect etiology, defect size, presence of exposed structures, CDC contamination score, Wagner grade, OFM graft usage, time to 100% granulation tissue, split-thickness skin graft (STSG) usage, overall time to heal and any post-operative complications. Patient demographics, baseline wound characteristics, and healing outcomes were analysed with descriptive statistics. Results / Discussion: 90% of patients had >1 significant co-morbidity (e.g. DM, PVD, PAD, cancer). Mean defect area was 84.2cm2 (+/-106.0). 54% of defects had concurrent osteomyelitis and 100% of defects were CDC Grade IV. The median number of applications to achieve 100% granulation tissue over exposed bone and tendon was 1 (one). Wounds surgically managed with OFM achieved viable granulation tissue covering exposed vital structures effectively shortening overall treatment times. Mean time to 100% granulation tissue over exposed bone and tendon was 26.0 days (+/-22.2 days). Of the patients who received a STSG, mean % STSG take at 1 week was 74.6%+/-18%. All patients went on to heal, with no surgical complications reported. Conclusion: This IRB-approved retrospective case series demonstrated OFM as a clinically effective treatment modality in the surgical management of complex lower extremity soft tissue defects with exposed structures and multi-morbid patients. [ABSTRACT FROM AUTHOR] |
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