| Autor: |
Marti-Marti, Ignasi, Podlipnik, Sebastian, Cañueto, Javier, Ferrándiz-Pulido, Carla, Deza, Gustavo, Sanmartín, Onofre, Jaka, Ane, Beà-Ardèbol, Sonia, Botella-Estrada, Rafael, Redondo, Pedro, Turrión-Merino, Lucía, Ruiz-Salas, Verónica, Masferrer, Emili, Yébenes, Mireia, Sánchez-Schmidt, Júlia-María, Gracia-Darder, Inés, Altemir-Vidal, Arcadi, Aguayo-Ortiz, Rafael S., Becerril, Sara, Bodet-Castillo, Domingo |
| Zdroj: |
Journal of the American Academy of Dermatology; Jul2023, Vol. 89 Issue 1, p119-127, 9p |
| Abstrakt: |
Satellitosis or in-transit metastasis (S-ITM) has clinical outcomes comparable to node-positivity in cutaneous squamous cell carcinoma (cSCC). There is a need to stratify the risk groups. To determine which prognostic factors of S-ITM confer an increased risk of relapse and cSCC-specific–death. A retrospective, multicenter cohort study. Patients with cSCC developing S-ITM were included. Multivariate competing risk analysis evaluated which factors were associated with relapse and specific death. Of a total of 111 patients with cSCC and S-ITM, 86 patients were included for analysis. An S-ITM size of ≥20 mm, >5 S-ITM lesions, and a primary tumor deep invasion was associated with an increased cumulative incidence of relapse (subhazard ratio [SHR]: 2.89 [95% CI, 1.44-5.83; P =.003], 2.32 [95% CI, 1.13-4.77; P =.021], and 2.863 [95% CI, 1.25-6.55; P =.013]), respectively. Several >5 S-ITM lesions were also associated with an increased probability of specific death (SHR: 3.48 [95% CI, 1.18-10.2; P =.023]). Retrospective study and heterogeneity of treatments. The size and the number of S-ITM lesions confer an increased risk of relapse and the number of S-ITM an increased risk of specific-death in patients with cSCC presenting with S-ITM. These results provide new prognostic information and can be considered in the staging guidelines. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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