| Autor: |
A., Pérez Jardón, A. I., Lorenzo Pouso, V. C., Alberto Caponio, C. M., Chamorro Petronacci, C., Menéndez Valdés, M., Pérez-Sayáns |
| Předmět: |
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| Zdroj: |
Medicina Oral, Patologia Oral y Cirugia Bucal; 2023 Supplement, Vol. 28, pS17-S17, 1/3p |
| Abstrakt: |
Introduction: Chronic hyperplastic candidiasis (CHC) is a prototypical oral lesion caused by chronic Candida infection. A significant controversy surrounding CHC is whether this oral lesion owns malignant transformation (MT) potential. Objectives: The present study aimed to evaluate the current evidence on the MT of CHC and determine the variables that significantly influence cancer development. Material and Methods: Bibliographical searches included PubMed, Embase, Web of Science, Scopus, and LILACS. The cohort studies and case series used to investigate the MT of CHC were deemed suitable for inclusion. The Joanna Briggs Institute scale measured the quality of the enrolled studies. Moreover, we undertook subgroup analyses, assessed minor study effects, and conducted sensitivity analyses. Results: From 338 studies, nine were finally included for qualitative/quantitative analysis. The overall MT rate for CHC across all studies was 12.1% (95% confidential interval, 4.1–19.8%). Subgroup analysis showed that the MT rate increased when the pooled analysis was restricted to poor-quality studies. Conclusions: According to the retrieved evidence, it remains complex to affirm whether CHC is an individual and oral, potentially malignant disorder. Prospective cohort studies to define the natural history of CHC and a consensus statement to clarify proper diagnostic criteria are strongly needed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Supplemental Index |
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