Lung Function of Preterm Children Parsed by a Polygenic Risk Score for Adult COPD.
Autor: | Nissen, Gyde, Hinsenbrock, Svenja, Rausch, Tanja K., Stichtenoth, Guido, Ricklefs, Isabell, Weckmann, Markus, Franke, Andre, Herting, Egbert, König, Inke R., Kopp, Matthias V., Rabe, Klaus F., Göpel, Wolfgang |
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Předmět: |
RISK factors of environmental exposure
PREMATURE infant diseases SINGLE nucleotide polymorphisms REGRESSION analysis RISK assessment VITAL capacity (Respiration) BRONCHITIS OBSTRUCTIVE lung diseases PULMONARY function tests FORCED expiratory volume GENETIC profile DISEASE risk factors DISEASE complications ADULTS |
Zdroj: | NEJM Evidence; Mar2023, Vol. 2 Issue 3, p1-10, 10p |
Abstrakt: | Background: Chronic obstructive pulmonary disease (COPD) in adults is a result of environmental risk factors and genetic factors. Polygenic COPD risk scores are highly predictive for lung function in adults. We hypothesized that a polygenic COPD risk score is also predictive for lung function in children who are born preterm. Methods: Infants with a birth weight of less than 1500 g (n=17,394) were enrolled in the German Neonatal Network. Among these children, we included those with chip genotyping and 5-year follow-up assessment (n=1957) in this analysis. A polygenic COPD risk score derived in adults with COPD was calculated on the basis of 1,637,882 single-nucleotide polymorphisms associated with forced expiratory volume within 1 second (FEV |
Databáze: | Supplemental Index |
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