| Autor: |
LEI, Y.-N., LI, X.-Y., GAO, G., WANG, W.-Y., LIANG, Z.-Y., WANG, Y.-S. |
| Zdroj: |
European Review for Medical & Pharmacological Sciences; Feb2023, Vol. 27 Issue 4, p1436-1442, 7p |
| Abstrakt: |
BACKGROUND: Immune-related hepatitis is one of the prevalent adverse events associated with immunotherapy, especially immune checkpoint inhibitors (ICIs). For patients without a history of liver disease, autoimmune disease, or alcohol consumption, it is not clear whether immune-related hepatitis could rapid progress to immune-related cirrhosis. CASE REPORT: We report the case of a 54-year-old female with stage IIIB primary pulmonary lymphoepithelioma-like carcinoma (PLELC) diagnosed with immune-related hepatitis. After 15 months, a liver biopsy demonstrated the rapid progression of liver cirrhosis although systematic corticosteroid administration. CONCLUSIONS: Long-term immune activation caused by ICIs may exacerbate the process of cirrhosis. Great attention should be paid to the rapid progression to liver cirrhosis of immune-related hepatitis in the clinic. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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