| Autor: |
Astuti, Lilies Anggarwati, Yani, Sinar, Asfirizal, Verry, Fikriah, Ika |
| Předmět: |
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| Zdroj: |
Journal of International Dental & Medical Research; 2022, Vol. 15 Issue 4, p1422-1428, 7p |
| Abstrakt: |
Root canals that are potentially contaminated with microorganisms when the gingiva is inflamed require periodontal pocket therapy to eliminate or reduce the microbial population and biomechanically remove necrotic tissue in the root canal system. Sarang Semut (Myrmecodia pendens) extract has the effectiveness as an antibacterial containing chemical compounds from the flavonoid and tannin groups. In many cases, flavonoids can act directly as antibiotics by interfering with the function of bacterial or viral microorganisms. The high rate of failure of periodontal treatment caused by the activity of several anaerobic and aerobic bacteria and there has been no research on the Sarang Semut plant used as a material for periodontal pocket irrigation and mouthwash, so a study was conducted to determine the acute toxicity of the Sarang Semut extract (Myrmecodia pendens) as a base material. Irrigation therapy for periodontal pockets and gingivitis. Data were analyzed using ANOVA test and regression test. The type of research conducted is experimental laboratory. Acute toxicity test of ethanol extract of Sarang Semut (Myrmecodia pendens) in Wistar Male rats (Rattus Norvegicus) at a dose of 0.1 g/kg BW on histology of the liver and kidneys had minimal toxic effect 7 days after application with minimal inflammatory cell infiltration. This dose can be used as a basic reference for periodontal pocket irrigation therapy. Further research is needed to formulate Myrmecodia pendens extract at lower dose yet effective for mouthwash preparations or for liquid periodontal pocket irrigation materials. [ABSTRACT FROM AUTHOR] |
| Databáze: |
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