| Autor: |
Rodilla, Enrique, Mendizábal, Andrea, Jiménez, Iratxe, Pérez, Leticia, Canales, Sergio, Roldán, Alicia, Pintos, Santiago, Catalán, Marta, Sáez, María-Carmen, Chordá, José, Costa, José-Antonio |
| Předmět: |
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| Zdroj: |
Artery Research; 2023 Supplement, Vol. 29 Issue 1, pS10-S11, 2p |
| Abstrakt: |
Background: 2018 ESC-ESH Guidelines for the Management of Arterial Hypertension recommend pharmacological treatment if patients with grade 1 HTN at low-moderate risk remain hypertensive after a period of lifestyle intervention. Our objective was to assess the predictive value of early vascular aging (EVA) to identifying patients who developed sustained HTN after baseline diagnosis. Methods: Retrospective, descriptive, longitudinal study including all consecutive patients referred to a HTN Unit with suspected naïve HTN without prior pharmacological treatment. EVA was defined according to estimated pulse wave velocity (brachial oscillometry, Mobil-O-Graph (IEM®) in seven age-groups(1). Standard clinical tests were performed at baseline and after 12 months. Results: Since 2010, 335 consecutive patients entered the study, with 201 women (60%), a mean age of 46,4 years (± 13), mean office BP of 130/76 (± 12/9), and ambulatory BP of 122/78 (± 8/7) mmHg. Distribution of BP was 155 (46.3%) patients with high-normal BP, 28 (8,4%) with white-coat HTN, 108 (32.2%) with masked HTN and 44 (13.1%) with established HTN. At baseline, 57% of patients showed EVA, after a mean time of 1.1 year, 65% of participants presented elevated ABPM. In univariate analysis, baseline stiffness (EVA) was associated with elevated ABPM-values in the follow-up visit (OR: 2.0; IC 1.3-3.1; p = 0.003). After adjustment for age, gender and pulse pressure, baseline EVA kept its significant predictive value (OR:2.6; IC 1.6-4.2; p = 0.001). Conclusions: Arterial damage characterized as EVA according to estimated PWV by brachial oscillometry doubles the probability of sustained HTN one year after initial assessment in naïve patients with high-normal BP/grade 1 HTN at low-moderate risk. [ABSTRACT FROM AUTHOR] |
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